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Usually found as a yellow, sometimes waxy, crystal-like substance, occasionally as a powder.
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Smoked: it can be inhaled through a pipe, and smoked in a joint. This is the preferred method and usually easier to do in the ‘freebase’ form.

Injected: it can be injected only if it is in the acidic salt (fumarate) form, the other form (‘freebase’) cannot be as it does not mix with water.

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Ingested: in some cultures, the ‘ayahuasca’ beverage contains some DMT. However, when ingesting DMT, an appropriate enzyme inhibitor must be taken (i.e. MAOIs), otherwise the DMT will be inactive.

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A statistically significant and clinically relevant reduction in depressive symptoms two weeks following a dose of SPL026 with supportive therapy, compared to placebo, demonstrating a -7.4 point difference in Montgomery–Åsberg Depression Rating Scale (MADRS) (p=0.02)
Analysis of key secondary endpoints demonstrated a rapid onset of antidepressant effect one-week post-dose, with a statistically significant difference in MADRS score between the active and placebo groups of -10.8 (p=0.002)
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Other forms exist as well but produce a very different experience — such as 4-AcO-DMT (more similar to psilocybin than DMT), 5-Bromo-DMT (very mild psychoactive effects), and 4-OH-DMT (the chemical name for psilocin). These compounds are technically a form of DMT, but are considered an entirely different class than N,N,DMT or 5-MeO-DMT.

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